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KMID : 0614620110570060346
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Korean Journal of Gastroenterology
2011 Volume.57 No. 6 p.346 ~ p.351
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Molecular and Clinical Characterization of Hepatitis A Virus in Gwangju and Jeonnam Province
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Noh Du-Young
Cho Sung-Bum
Kim Yeon-Ju
Lee Wan-Sik
Park Chang-Hwan
Joo Young-Eun
Kim Hyun-Soo
Rew Jong-Sun
Choi Sung-Kyu
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Abstract
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Background/Aims: Dominant genotype of hepatitis A virus (HAV) in Korea had been known to be genotype 1A in 1990s. Recently, the epidemiologic change of HAV genotype was reported with an upsurge of acute hepatitis A in Korea. The aim of this study was to investigate the change of HAV genotypes and clinical characteristics in Gwangju and Jeonnam province.
Methods: From November 2008 to October 2009, a total of 82 patients with acute hepatitis A were enrolled prospectively. HAV genotype was determined using reverse transcriptase polymerase chain reaction and sequencing of the PCR products of VP1/2A region of HAV.
Results: HAV RNA was detected in 82% (67/82). The genotype IIIA (88%, 59 cases) was significantly more frequent than genotype IA (12%, 8 cases) (p>or=0.01). The subtypes of genotype IIIA were AJ299467 Norway (49%), HA-JNG04-09 Japan (27%), HS-14-12-00 Spain (22%) and H-122 Sweden (2%). The subtypes of IA were FH1 Japan (50%) and HA J04-3 Japan (50%). The substitutions of amino acid were more frequent in genotype IIIA than IA (p>or=0.01). There was no difference in the clinical characteristics between the patients with genotype IIIA and IA.
Conclusions : Genotype IIIA was a dominant genotype of recent HAV infection in Gwangju and Jeonnam province. This study provides valuable epidemiologic information of genetic distributions of HAV in Korea.
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KEYWORD
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Hepatitis A virus, Genotype, Epidemiology
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